Which of the following symptoms is NOT associated with cholestasis?

Cholestasis is a condition that involves impaired bile flow, which can lead to a build-up of bile acids in the bloodstream. It is typically characterized by several symptoms that result from this excess of bile acids.

Pruritus without lesions, mild jaundice, and anorexia are all common symptoms associated with cholestasis. Pruritus, or itching, occurs due to the accumulation of bile salts in the bloodstream, often affecting the palms of the hands and the soles of the feet primarily. Mild jaundice, which is the yellowing of the skin and eyes, can occur when there is an excess of bilirubin in the blood as a result of liver dysfunction or bile flow obstruction. Anorexia, or loss of appetite, can also be a symptom due to the associated discomfort and changes in liver function.

On the other hand, severe headaches are not typically associated with cholestasis. While headaches can occur in a variety of conditions and may be influenced by stress or other factors, they are not a direct symptom of cholestasis. Therefore, recognizing that headaches do not relate to the pathophysiology of cholestasis helps to clarify why this option is the correct choice in this context.