What does pruritus refer to in the context of cholestasis symptoms?

Pruritus, in the context of cholestasis symptoms, specifically refers to itching without lesions. This condition arises due to the accumulation of bile acids in the bloodstream, which can occur when bile flow is obstructed or impaired. In cholestasis, the deposition of these substances in the skin can lead to an intense itching sensation, often experienced especially on the palms and soles.

This symptom is significant, as it can be one of the earliest indicators of liver dysfunction related to cholestasis, prompting further investigation into the underlying causes. Unlike options that describe pain, rash, or redness, pruritus is characterized purely by the sensation of itchiness without any visible skin changes, making it a unique symptom that healthcare providers should recognize in patients with liver or bile duct issues.